Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

Article Abstract:

The DNA binding orphan receptor CAR-beta acts as a heterodimer with the retinoid-X receptor, activating gene transcription in a constitutive way. The constitute activity of CAR-beta is shown to result from a ligand-independent recruitment of transcriptional co-activators. The steroids androstanol and androstenol were found to inhibit constitutive activity of CAR-beta, but do not interfere with the heterodimerization or DNA binding of CAR-beta.

Observations, Carrier proteins, Transport proteins, Androstane

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Interaction of thyroid-hormone receptor with a conserved transcriptional mediator

Article Abstract:

Experimental studies of a yeast two-hybrid system suggest the ability of the thyroid-hormone-receptor interacting protein (Trip1), which possesses structural homology with the transcriptional mediator Sug1, to react in vitro with the regulatory protein GAL4's activation domain and with the thyroid-hormone receptor. This implies a role of Trip1 as a transcription activator in yeast.

Analysis, Physiological aspects, Genetic aspects, Hormone receptors, Genetic transcription, Transcription (Genetics), Yeast, Yeast (Food product)

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

Article Abstract:

The nuclear receptor CAR is found to mediate the response induced by xenobiotics.

Research, Neural receptors, Drug metabolism

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