Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Article Abstract:

The excitatory synapses onto higher indirect-pathway medium spiny neurons (MSNs) have displayed higher release probability and larger N-methyl-D-aspartate receptor currents than direct-pathway synapses. The results have helped in understanding the normal functions of the basal ganglia and have suggested different methods for developing the therapeutic drugs for treating striatal-basal brain disorders like Parkinson's disease and Huntington's disease.

United States, Genetic aspects, Parkinson's disease, Parkinson disease

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Spatial learning without NMDA receptor-dependent long-term potentiation

Article Abstract:

The N-methyl-D-aspartate (NMDA) receptor-mediated long-term potentiation (LTP) is not essential for normal spatial learning. Both the non-spatially pretrained and the control rats give efficient watermaze performance. The NMDA receptor antagonist 2R,4R,5S-2-amino-4,5-(1,2-cyclo hexyl)-7-phosphonoheptano acid inhibits the dentate gyrus LTP in rats but has no effect on the normal spatial learning in watermaze.

Research, Hippocampus (Brain), Learning in animals, Animal learning, Rats as laboratory animals, Laboratory rats

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