Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

Article Abstract:

Tyrosine kinases lie upstream Ras in a signalling cascade. This cascade transduces signals, where Grb2 is the central protein and has all the attributes of an adaptor that binds receptors to mSos. Grb2 links up with mSos1 through 2SH3 group or it links up with tyrosine kinase through SH2 group. This function is universal to all cell types. When GTP is loaded to Ras, the loading activates Ras proteins enabling it to transmit signals as shown with experiments conducted on rat cells. The signal transduction cascade represents only one of the many ways tyrosine can affect Ras function.

Analysis, Cell receptors, Nucleotides

---

Protein tyrosine kinase PYK2 involved in Ca2+ -induced regulation of ion channel and MAP kinase functions

Article Abstract:

The protein tyrosine kinase PYK2 is activated by increased intracellular calcium caused by membrane depolarization and ion channel activation through various extracellular stimuli. However, it is also most likely involved in the regulation of ion channel functions and could be the intermediary between G-protein-coupled receptors' activating neuro-peptides and neuronal activity regulatory signalling events. Therefore, PYK2 may be autoregulatory while also influencing neuronal cell gene expression through calcium-mediated regulation.

Calcium ions, Physiological regulation, Biological control systems, Ion channels

---

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Article Abstract:

Proteins encoded by the mammalian shc gene (Shc) are phosphorylated by tyrosine in growth-factor stimulated cells and form a specific complex with a non-phosphorylated protein encoded by the grb2/sem-5 gene (Grb2/Sem-5). Both gene products contain SH2 domains which mediate their binding to form that complex. Experiments based on shc overexpression in PC12 cells combined with what is known about the role of tyrosine kinases suggest that the Shc-Grb2/Sem-5 complex regulates the Ras signalling pathway.

Ras genes

Similar abstracts:

• Abstracts: Beef carcass composition of slaughter cattle differing in frame size, muscle score, and external fatness. Retail cut yields of Rambouillet wether lambs fed the beta-adrenergic agonist L(sub 644,969)
• Abstracts: Combinations of rendered protein meals for growing calves. Effect of grain sorghum hybrid on in vitro rate of starch disappearance and finishing performance of ruminants
• Abstracts: Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume. Gating of the voltage-dependent chloride channel ClC-0 by the permeant anion
• Abstracts: A technical KO of amyloid-beta peptide. Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.