Associative, bidirectional modifications at the hippocampal mossy fibre-CA3 synapse
Article Abstract:
The mossy fibre-CA3 synapse shows heterosynaptic, homosynaptic and associative long-term depression (LTD) in vivo. Synaptic conditions that are insufficient for inducing long-term potentiation (LTP) gives rise to mossy fibre LTD. LTP and LTD are cellular mechanisms for storing information in the brains of vertebrates. The CA3 afferents are capable of providing some conditions for LTP, and LTD is induced in an associative manner. This suggests a role for LTP and LTD in information storage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Selective activation of Ca2 plus- activated K plus channels by co-localized Ca2 plus channels in hippocampal neurons
Article Abstract:
The activation of potassium channels by calcium entry in hippocampal neurons underlies an action potential down phase. Calcium channel subtypes undergo selective coupling to calcium-activated potassium channels. Cell types may differ in terms of the way that this coupling is achieved. Microdomains could supply inihibitory coupling from from L-type calcium channel to another in the heart. Selective functional coupling has been achieved using submembrane calcium microdomains.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Reverse replay of behavioral sequences in hippocampal place cells during the awake state
Article Abstract:
A study conducted reports that sequential replay occurs in the rat hippocampus during awake periods immediately after spatial experience. The replay is suggestive of a role in the evaluation of event sequences in the manner of reinforcement learning models, which might constitute a general mechanism of learning and memory.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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