Better cells for brain repair

Article Abstract:

Two new approaches for brain cell repair are presented. The first approach was developed during research for an effective way to treat Parkinson's disease. It involves the use of myoblast cells genetically engineered to produce tyrosine hydroxylase. Transplantation of the engineered myoblasts in the striatum of Parkinsonian rats did not induce rejection, and expressed the TH gene at a stable level during the six-month duration of the experiment. A second approach involves the use of oligodendrocyte precursors to remyelinate demyelinated axons. This second approach appears to have more promise than intracerebral transplantation.

Care and treatment, Gene therapy, Nervous system, Nerve regeneration

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Prospects for new restorative and neuroprotective treatments in Parkinson's disease

Article Abstract:

It has been established that there is gene linkage in rare families with strong patterns of inheritance of Parkinson's disease-like disease. This discovery, along with the identification of the individual genes involved, has given new information about the involvement of particular genes and molecules, especially alpha-synuclein, in Parkinson's disease. This disease is progressive in nature, with slow neuronal degeneration in the substantia nigra. This means that there are opportunities for therapeutic intervention designed to block or slow down the degenerative process.

Causes of

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Self-repair in the brain

Article Abstract:

Self-repair in the brain is examined.

Neurobiology, Self-repair capability, Self repair capability

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