Big engine finds small breaks

Article Abstract:

Most communities maintain an impressive collection of hardware for dealing with major emergencies. A double strand break in DNA is the cellular equivalent of a three-alarm fire. RecBCD aids in the repair of double strand breaks that occur during normal DNA replication and due to damage by ionizing radiation.

Influence, Ionizing radiation

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Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control

Article Abstract:

The mitotic CDK, Clb2/Cdc28, binds tightly into an amino-terminal domain (NTD) of Cdc6 that is unable to assemble pre-RCs. The evidence indicating that the Clb2-dependent mechanism prevents replication in vivo is presented.

Analysis, Protein binding, Phosphorylation

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Replication and protection of telomeres

Article Abstract:

The article discusses the interaction of telomeres which consist of genetic deoxyribonucleic (DNA) proteins, with the DNA replication and damage repair mechanism in an organism.

Telomeres

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