Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
Article Abstract:
A study reports that bone morphogenetic proteins (BMPs) trigger a significant reduction in the stem-like, tumour-initiating precursors of human glioblastomas (GBMs). The analysis has shown that the BMP-BMPR (BMP cognate receptor) signalling system acts as a key inhibitor of tumour-initiating, stem-like cells from GBMs and has identified BMP4 as a novel, non-cytotoxic therapeutic effector, which might be used to prevent growth and recurrence of GBMs in humans.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
Article Abstract:
A biochemical and genetic evidence for a dual-kinase mechanism for LRP6 (LDL-receptor related protein) whose phosphorylation is induced upon stimulation by Wnt is described. It is observed that Wnt induces phosphorylation of LRP6 by GSK3 and casein kinase 1 and promotes the engagement of LRP6 with axin and with GSK3 acting as a genuine switch that dictates both on and off states of a pathway.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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