Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

Article Abstract:

The structure of botulinum neurotoxins (BoNTs) is reported in complex with its protein receptor, which binds the domain of botulinum neurotoxin sero type B (BoNT/B) bound to the luminal domain of synaptotagmin II. The findingss provide the basis for the rational development of preventive vaccines or inhibitors against these neurotoxins.

Botulinum toxin, Botulinum toxins, Protein research

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Structural basis of cell surface receptor recognition by botulinum neurotoxin B

Article Abstract:

A 'double receptor' model in which botulinum neurotoxins (BoNTs) recognize nerve terminals via interactions with both gangliosides and protein receptors that mediate their entry is proposed. The crystal structure of full-lengthy BoNT/B in complex with the synaptotagmin II (Syt-II) recognition domain at 2.6 A resolution is reported.

Cell receptors, Gangliosides

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Substrate recognition strategy for botulinum neurotoxin serotype A

Article Abstract:

Clostridal neurotoxins (CNTS) are the causative agents of the neuroparalytic diseases botulism and tetanus. The first structure of a CNT endopeptidase in complex with its target SNARE at a resolution of 2.1 A: botulinum neurotoxin serotype A (BoNT/A) protease bound to human SNAP-25 is reported.

United States, Bacterial toxins, Tetanus, Botulism, Tetanus toxin

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