Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

Article Abstract:

It has been established that bradykinin- or nerve growth factor-mediated potentiation of thermal sensitivity in vivo needs expression of VR1, a heat-activated ion channel on sensory neurons. It was possible to identify a biochemical mechanism through which bradykinin and nerve growth factor create hypersensitivity.

Nerve growth factor, Bradykinin

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Spider toxins activate the capsaicin receptor to produce inflammatory pain

Article Abstract:

Venom from a tarantula that is native to the West Indies is shown to contain three inhibitor cysteine knot (ICK) peptides that target the capsaicin receptor (TRPV1), an excitatory channel expressed by sensory neurons of the pain pathway. The TRP channels are included among the targets of peptide toxins, showing that animals, like plants, avert predators by activating TRP channels on sensory nerve fibers to elicit pain and inflammation.

Health aspects, Pain, Pain management, Composition, Capsaicin, Spider venom, Spider venoms

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The menthol receptor TRPM8 is the principal detector of environmental cold

Article Abstract:

The cultured sensory neurons and intact sensory nerve fibers from transient receptor potential melastatin 8 deficient mice exhibit profoundly diminished responses to cold and behavioral deficits to discriminate between warm and cold surfaces.

Science & research, Physiological aspects, Sensory receptors, Ion channels, Nerves, Peripheral, Peripheral nervous system

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