Calmodulin supports both inactivation and facilitation of L-type calcium channels

Article Abstract:

Calmodulin is a vital Ca2+ sensor for both inactivation and facilitation. Residues within the consensus calmodulin-binding isoleucine-glutamine (IQ) motif significant for calmodulin binding determine the nature of the modulatory effect. It has also been shown that a putative IQ motif in the cytoplasmic tail of alpha-1C binds to calmodulin and is also significant for the opposing modulatory actions. Mutation of Ile 1624 to alanine inhibits Ca2+-dependent inactivation.

Calcium-binding proteins, Calcium binding proteins

---

A modular switch for spatial [Ca.sup.2+] selectivity in the calmodulin regulation of [Ca.sub.v] channels

Article Abstract:

The development of a modular switch for the spatial [Ca.sup.2+] selectivity in the calmodulin (CaM) regulation of [Ca.sub.v] channels is discussed. The findings show that the spatial [Ca.sup.2+] selectivity can be easily switched by a novel CaM-binding site within the amino terminus of channels.

Measurement, Electric properties, Voltage, Electric potential, Chemical properties

---

Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels

Article Abstract:

Research is presented describing how calcium channels in the brain are affected by calmodulin. In order to simplify the study of molecular mechanisms, researchers studied recombinant P/Q-type calcium channels in HEK293 cells in mammals.

Similar abstracts:

• Abstracts: Deactivation and reactivation of somatosensory cortex after dorsal spinal cord injury. Evolving ideas of brain evolution
• Abstracts: Chromatin organization and cell fate switch respond to positional information in Arabidopsis. The Ph1 locus is needed to ensure specific somatic and meiotic centromere association
• Abstracts: Visible flicker from invisible patterns. Realignment of cones after cataract treatment. Orientation-selective adaptation and tilt after-effect from invisible patterns

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.