Two levels of protection for the B cell genome during somatic hypermutation

Article Abstract:

The extensive sequencing of the murine B cell genes is employed to explain the two mechanisms involved in the protection of the genome by somatic hypermutation. The findings reveal that the ultimate distribution of the mutations is highly determined by the balance between high-fidelity and error-prone DNA repair.

Genetic aspects, DNA repair, B cells, Mutation (Biology), Mutation

---

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Article Abstract:

The discovery of new pathway that prevents autoimmunity by limiting the levels of T lymphocytes of a co-stimulatory receptor, the inducible T-cell co-stimulator (ICOS) is described.

Analysis, Protein synthesis, T cells, Protein biosynthesis, Messenger RNA, Immune response, Structure

---

Similar abstracts:

• Abstracts: Function and mechanism of mirror-image ambiguity in bumblebees. How do bumblebees first find flowers? Unlearned approach responses and habituation
• Abstracts: Structural and mechanistic insights into the interaction between Rho and mammalian Dia. A structural basis for allosteric control of DNA recombination by lambda integrase
• Abstracts: Structural and mechanistic insights into the interaction between Rho and mammalian Dia. part 2 Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases
• Abstracts: Colloids get complex. Mechanism limiting centrosome duplication to once per cell cycle. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin
• Abstracts: The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Megabase deletions of gene deserts results in viable mice

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.