Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

Article Abstract:

The conserved leucine residues in nicotinic receptors' M2 (9') domains appear to be an important part of the channel gating mechanism. Closed channels have Leu 9' residues occluding the conduction pathway while opening channels rotate the Leu 9' side chains away from the pathway. Sensitivity to agonists is increased and desensitization is slowed when the Leu 9' residue is mutated to other residues. The mutated and wildtype Leu 9' residues are compared using stoichiometry of muscle in naChR.

Physiological aspects, Leucine, Nicotinic receptors

---

P2X receptors as cell-surface ATP sensors in health and disease

Article Abstract:

Discoveries regarding P2X receptors, membrane ion channels activated by adenosine triphosphate (ATP)-binding, reveal that they play an important role in the nervous system, afferent signaling, chronic pain, and in autocrine loops of endothelial and epithelial cells. They have a distinct molecular structure and unique functional properties, of possible use in novel therapeutics for human diseases.

United States, Science & research, Ion channels, Adenosine triphosphatase, ATPases, Purine nucleotides

---

State-dependent cross-inhibition between transmitter-gated cation channels

Article Abstract:

A study of transmitter-gated cation channels is presented with reference to their use as detectors. The influence of structurally independent channels on each other is discussed in particular their state-dependent cross-inhibition.

Letter to the Editor, Chemical detectors, Neurotransmitters

Similar abstracts:

• Abstracts: Charge separation in localized and delocalized electronic states in polymeric semiconductors. Efficient photodiodes from interpenetrating polymer networks
• Abstracts: Crystal structure of nerve growth factor in complex with ligand-binding domain of the TrkA receptor. Peptide exosite inhibitors of factor Vlla as anticoagulants
• Abstracts: Interpopulation and context-related differences in responses of a marine gastropod to predation risk. A transmissible trematode affects the direction and rhythm of movement in a marine gastropod
• Abstracts: The pulling power of galaxy clusters. The state of the Universe. Characterizing the nonlinear growth of large-scale structure in the Universe
• Abstracts: Diameter of the World-Wide Web. Darwin and Einstein correspondence patterns. Error and attack tolerance of complex networks

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.