Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

Article Abstract:

The human tripeptidyl peptidase II (TPPII) is a neuropeptidase that inactivates cholecystokinin (CCK). TPPII is a serine peptidase with a molecular mass of 135,000 and is irreversibly labeled on sodium dodecy sulphate-polyacrylamide gel electrophoresis. TPPII is present in the brain, liver, testis, kidney and spleen. It is both cytosolic and linked to the synaptonemal membranes. The enzyme is specific for CCK-8 which it breaks up into biologically inactive parts. Blockade of TPPII by butabindide prevents the inactivation of neuronal CCK-8. CCK-responsive neurons express TPPII.

Observations, Proteases, cholecystokinin

---

Selective inhibition of cocaine-seeking behavior by a partial dopamine D(sub3) receptor agonist

Article Abstract:

Environmental stimuli associated with the effects of abused drugs, particularly cocaine, may produce craving in abstinent human substance abusers. The first D(sub3)-receptor-selective agonist, BP897 was designed and assessed in vitro and in vivo with mice having disrupted D(sub3)-receptor genes. BP 897 was found to inhibit cocaine-seeking behaviour.

Prevention, Cocaine abuse, Drug abuse, Dopamine receptors

---

High constitutive activity of native H3 receptors regulates histamine neurons in brain

Article Abstract:

Research carried out concludes that H3 receptors are present in rat brains and control histaminergic neuron activity.

Analysis, Brain research

Similar abstracts:

• Abstracts: Human leptin characterization. Acute stimulation of glucose metabolism in mice by leptin treatment. Leptin and the regulation of body weight in mammals
• Abstracts: Inhibition of mutant troponin C activity by an intra-domain disulfide bond. Risky immortalization by telemerase
• Abstracts: Vision and attention: the role of training. Tracking an object through feature space. Intimate attention
• Abstracts: Travelling waves in vole population dynamics. Life-history traits of voles in a fluctuating population respond to the immediate environment
• Abstracts: Functional interaction of beta-catenin with the transcription factor LEF-1. Fluorescent pigments in corals are photoprotective

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.