Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member

Article Abstract:

The derailed (drl) gene present in Drosophila encodes the receptor protein-tyrosine kinase Drl which probably controls the selection of pathways by the developing neurons after activation by its ligand. This control is by the regulation of cell adhesion molecules which control the proper fasciculation of axons. The drl gene is expressed in a subset of embryonic interneurons whose growth cones choose similar pathways. These neurons in drl deficient individuals are unable to choose the correct pathways. The Drl protein is similar in structure to the mammalian RYK protein.

Physiological aspects, Genetic aspects, Proteins, Developmental neurology

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Axon routing across the midline controlled by the Drosophila Derailed receptor

Article Abstract:

Axons in the Drosophila embryo cross the midline in one of two distinct tracts, the anterior or posterior commissure. The Derailed (Drl) receptor tyrosine kinase is shown to be expressed by neurons projecting in the AC, and its absence such neurons can project abnormally into the PC. Drl is shown to be a novel component in the control of midline crossing.

Nervous system

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