Control of pain initiation by endogenous cannabinoids

Article Abstract:

Endogenous cannabionoids such as anandamide could contribute to the control of pain transmission in the central nervous system (CNS). An experiment shows that anandamide attenuates pain behaviour produced by chemical damage to cutaneous tissue, through interaction with CB1-like cannabinoid receptors outside the CNS. A similar effect is exerted by palmitylethanolamide (PEA), by activating CB2-like receptors. Together the two compounds act synergistically reducing pain responses more potently.

Prevention, Pain

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A second endogenous cannabinoid that modulates long-term potentiation

Article Abstract:

Cannabinoid receptors appear in parts of the central nervous system that contribute to memory, cognition, movement and pain perception, the same functions that can be strongly influenced by cannabinoid drugs. There is still a lack of information on the endogenous signalling system of cannabinoid receptors. A study found that cannabinoid ligand sn-2 arachidonylglycerol was present in the brain, and its formation is calcium dependent, and mediated by phospholipase C and diacylglycerol lipase.

Drug receptors

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Brain cannabinoids in chocolate

Article Abstract:

Chocolate contains unsaturated N-acylethanolamines that are capable of acting as cannabinoid mimics either by stimulating cannabinoid receptors in the brain or by increasing anandamide levels. The cannabinoids produce a sense of euphoria and enhance sensitivity. The increased levels of anandamide can cooperate with the pharmacological components of chocolate and generate a sense of well being.

Chocolate candies, Physiological aspects, Observations, Brain, Chocolate candy

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