Bax-independent inhibition of apoptosis by Bcl-x(sub l)

Article Abstract:

Interaction with Bax is unnecessary for Bcl-x(sub l) to inhibit apoptosis. Mutations of residues in Bcl-x(sub l), that bind to Bax or Bak, reduce its inhibitory activity to a small extent. Site-specific mutagenesis indicate that the amino acids required for the suppression of Sindbis virus-induced cell death by Bcl-x(sub l) are in the Bcl-2-homology regions 1 and 2. The amino acids necessary for the Bcl-x(sub l) activity are different from those necessary for Bcl-2 function.

Research, Observations, Mutation (Biology), Mutation

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X-linked IAP is a direct inhibitor of cell-death proteases

Article Abstract:

A recombinant XIAP protein and a cell free system was used to investigate human X-chromosome-linked inhibitor-of-apoptosis (IAP). IAP genes are important in regulating programme cell death in animals. Cell death can be suppressed by ectopic expression of human IAP proteins. The human X-chromosome linked IAP was found to directly inhibit cell death proteases caspase.

Genetic aspects

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