Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

Article Abstract:

The conditional paired box gene 5 (Pax5) deletion in mice has allowed mature B cells from peripheral lymphoid organs to differentiate in vivo back to early uncommitted progenitors in the bone marrow, which has rescued T lymphopoiesis in the thymus of T-cell-deficient mice. The complete loss of Pax5 in late B cells has initiated lymphoma development and has disclosed a plasticity of mature peripheral B cells despite their advanced differentiation stage.

Science & research, Genetic aspects, Cell differentiation, Bone marrow cells, Lymphocytes, Hematopoietic stem cell disorders

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LOng-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

Article Abstract:

Cloned Pax5-deficient pro-B cells placed into RAG2-deficient mice were found to give long-term reconstitution of the thymus and form mature T cells expressing alpha/Beta-T-cell receptors. Pax5 is thus implicated in the control of B-lineage commitment, and not immunoglobulin DJ rearrangement or expression of E2A, EBF, lambda5, VpreB, Igalpha and IgBeta.

Thymus, Thymus gland

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Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

Article Abstract:

The Pax5-gene is expressed in the haematopoietic system solely in the B-lymphoid lineage, although it is not required for in vitro propagation of pro-B cells in the presence of interleukin-7 and stromal cells. Pro-B cells lacking Pax5 are shown to be incapable of in vitro B-cell differentiation until restoration of Pax5 expression.

B cells

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