Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

Article Abstract:

A study has been conducted to examine the crystal structures of human calcineurin, an important protein in T-cell activation, and the human binding protein complex, FKBP12-FK506, which inhibit calcineurin after association with cytoplasmic binding proteins. Electron microscopy showed that an autoinhibitory element binds calcineurin at the Zn/Fe-containing active site to induce nucleophilic attack on the substrate phosphate by a metal-activated water molecule. Since the auto-inhibitory element is displaced in the FK-506-calcineurin complex, the protein complex is forced to share a binding site with inhibitors of calcineurin.

Research, Carrier proteins, Transport proteins, Phosphatases, Immunosuppression, Guadeloupe

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Crystal structure of an integral membrane light-harvesting complex from photosynthetic bacteria

Article Abstract:

The active assembly constitutes two concentric cylinders of helical protein subunits in which the pigment molecules are enclosed, as revealed from the crystal structure of the light-harvesting antenna complex from the photosynthetic bacterium Rhodopseudomonas acidophila strain 10050. A continuous overlapping ring is formed by 18 bacteriochlorophyll a molecules placed between the helices. The other nine bacteriochlorophylls are located among the outer helices. The carotenoid molecules number between 13 and 14 and are woven throughout the complex.

Models, Analysis, Observations, Morphology (Biology), Proteins, Morphology, Bacteria, Photosynthetic, Photosynthetic bacteria

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Is the university-industrial complex out of control?

Article Abstract:

Universities should closely monitor relationships with industry in order to maintain social accountability and public trust to avoid conflict of interests.

Management, Universities and colleges, Social policy, Science and technology policy, Industry, Industries, Academic freedom, University autonomy

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