Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Article Abstract:

Positional cloning has identified ferroportin1 as the gene responsible for the hypochromic anaemia of the zebrafish hypochromic blood mutant weissherbst. This gene encodes a multiple-transmembrane domain protein that is a candidate for the transporter thought to export iron across the basolateral surface to the circulation. This research involved isolating two independent autosomal recessive mutations of weh. It was found that weh mutant erythroid cells are fully capable of haemoglobinization, with hypochromia being the result of inadequate circulatory iron levels. In adults, Ferroportin1 probably acts in iron transport as the basolateral surface of duodenal enterocytes.

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Deficiency of gluataredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis

Article Abstract:

Iron is a required in order to produce haem and iron-sulphur (Fe-S) clusters, processes, which were thought to occur independently. Studies and findings have uncovered a connection between heam biosynthesis and Fe-S clusters, indicating hemoglobin production in the differentiating red cell is regulated through Fe-S cluster assembly.

United States, Health aspects, Sulfur, Sulphur, Hemoglobin synthesis

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Mitoferrin is essential for erythroid iron assimilation

Article Abstract:

Iron has a fundamental role in many metabolic processes, a zebrafish mutant, frascati (frs), that shows severe hypochromic anaemia and erythroid maturation arrest owing to defects in mitochondrial iron uptake. By positional cloning it is shown that the gene mutated in the frs mutant is a member of vertebrate mitochondrial solute carrier family, mitoferrin (mfrn), which is responsible for mitochondrial iron accumulation and functions as iron transporter, essential for heme synthesis in vertebrate erythroblasts.

Science & research, Mitochondria, Acculturation, Properties, Assimilation (Sociology)

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