Degenerin similarities

Article Abstract:

Recent research has identified the alpha-rENaC gene whose product causes amiloride sensitivity in Xenopus oocytes. This gene has marked similarity to the deg-1 and mec-4 genes of Caenorhabditis elegans. All three genes exhibit similarity over their entire length indicating they are of the same genetic family. The ability of alpha-rENaC to stimulate amiloride-sensitivity suggests that perhaps deg-l, mec-4 and the newly discovered mec-10 may be similarly involved in a sodium-channel complex and part of a mechanotransducing channel.

Reports, Genetic research, Molecular neurobiology

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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

Article Abstract:

It appears that Caenorhabditis elegans uses CTL-1 to deal with oxidative stress in the cytosol, where it could work with a superoxide dismutase. Counteracting cytosolic oxidative stress may permit animals to undergo long periods of pre-reproductive dormancy as dauer larvae. The cytosolic catalase could be a quite new acquisition for C. elegans and other nematodes, but an alternative view is that cytosolic catalases could be quite general and used especially during periods of nutrient reduction.

Cytosol

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A stomatin-like protein necessary for mechanosensation in C. elegans

Article Abstract:

The stomatin-like mec-2 protein (MEC-2) connects the mechanosensory transduction channels and the microtubule cytoskeleton of the touch receptor neurons, in Caenorhabditis elegans. This connection causes a mechanosensation resulting in channel opening due to microtubule displacement. The region between the hydrophobic domain and the carbonyl end of the human stomatin resembles the MEC-2. The touch receptor axons contain MEC-2-Lac Z fusions.

Observations, Proteins, Neurons

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