Developing B-cell theories

Article Abstract:

In clonal selection in the adaptive immune response B and T cells have a diverse array of antigen receptors before encountering antigens. New studies have indicated that assembly of antigen-receptor genes in mature B cells, may be reactivated in response to antigen. Two research groups report a new tool that may enable a more sophisticated analysis of B and T cell development. One group used a large reporter transgene comprising RAG chromosomal regions with GFP substituted fro RAG2, while the other group created mice where the endogenous RAG2 locus directs expression of a RAG2-GFP fusion protein. Each group detected a subset of RAG-expressing B cells in the spleen.

Observations, B cells, Immunological research, Immunologic research

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Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes

Article Abstract:

Research into the involvement of DNA double-strand breaks (DSBs) in somatic hypermutation of immunoglobulin variable region genes is presented. A model is presented to show how the processing of DSBs results in the introduction of mutations into the DNA.

Gene mutations, Gene mutation

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

Article Abstract:

Research is presented concerning the diversification of immunoglobulin V genes, following gene rearrangement, by gene conversion or by somatic hypermutation. The physiological aspects of hypermutation are discussed.

Physiological aspects, Nucleotides

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