Dispersion of neural progenitors within the germinal zones of the forebrain

Article Abstract:

The movement of labelled stem cells in the ventricular zones of the dorsal and basal regions of the E15 murine telencephalon was observed over an 8-24-hour period. The aim was to investigate the mechanism for the establishment of regional diversity in the forebrain during early neurogenesis. The results showed that stem cell movement was extensive in the plane of the cortical ventricular zone, but was restricted at the border between the cortical ventricular zone and the basal telencephalic ventricular zone. This suggests that restriction of cell movements may be one mechanism for establishing regional diversity in the developing forebrain.

Stem cells, Developmental neurology, Cell migration, Prosencephalon

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The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS

Article Abstract:

New research has emphasized the role of the roof plate in normal central nervous system development. It was found that the phenotype of the spontaneous neurological mutant mouse dreher is caused by a failure of the roof plate to develop. This in turn has an impact on dorsalization of the neural tube. It is suggested that, as in more caudal regions of the embryo, the roof plate could be vital for dorsal patterning within the cerebellum. It may be possible to extend the general model of dorsal fate specification to rostral areas of the developing nervous system.

Abnormalities, Neural tube, Vertebrae, Thoracic, Thoracic vertebrae, Neural tube defects

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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

Article Abstract:

A large-scale screen to create an atlas of Central Nervous System (CNS) gene expression at the cellular level, and to provide a library of verified bacterial artificial chromosomes (BAC) vectors and transgenic mouse lines that offer experimental access to CNS regions, cell classes and pathways are described.

Science & research, Genetic aspects, Central nervous system, Brain research, Artificial chromosomes

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