Double-stranded RNA poses puzzle
Article Abstract:
Fire et al have reported on a technique for the inhibition of gene functions by turning off a gene in the nematode worm through the microinjection of double-stranded RNA (dsRNA). Interference appears to occur at the chromosomal level, or through a catalytic mechanism. The finding gives rise to a number of questions, such as whether a biological function is performed by dsRNA. This method of inhibiting gene expression can provide an alternative for assessing gene function in nematode worms, and may also be useful for other forms of life.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Regulation of serotonin-2C receptor G-protein coupling by RNA editing
Article Abstract:
The physiological effects of the 2C subtype belonging to the neurotransmitter serotonin family of receptors are found to be regulated through RNA editing. This is achieved by converting genomically-encoded adenosine residues to inosines. RNA editing can play important roles in regulating cellular functions in the G-protein-coupled receptor superfamily and controlling serotonergic signal transduction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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