Dwarf mice and the aging process
Article Abstract:
The small body size, reduced metabolic rate and hypogonadism could be the causes of increased longevity in Ames dwarf mice. These mice are deficient in growth hormone (GH), prolactin and thyroid stimulating hormone. The lifespan of the dwarf mice is 350 days to 470 days more than that of the normal mice under ordinary laboratory conditions. The deficiency in GH and insulin-like growth factor-I may be crucial in the delayed aging process in these mice as overexpression of GH is linked to reduced lifespan in transgenic mice.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
Article Abstract:
The case of mice exhibiting a lack of cyclooxygenase 2 (COX-2) is discussed with relation to inflammation and renal characteristics. The method used in identifying the deficiency was gene targeting. COX-2 is one of two main determinants in the regulation of prostaglandin synthesis. The regulation of the latter is important in the production of anti-inflammatory substances such as drugs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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No red cell is an island
Article Abstract:
Red blood cells develop in the bone marrow in 'islands' nurtured by a central white blood cell. A study on mice shows that the retinoblastoma protein is crucial for these white cells to mature and form islands.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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