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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

EphB receptor activity suppresses colorectal cancer progression

Article Abstract:

A demonstration that although Wnt signaling remains constitutively active, most human colorectal cancers lose expression of EphB at the adenoma-carcinoma transition is presented. EphB guidance receptors are Tcf4 target genes that control intestinal epithelial architecture through repulsive interactions with Ephrin-B ligands.

Author: Gallinger, Steven, Pawson, Tony, Clevers, Hans, Begthel, Harry, Battle, Eduard, Bacani, Julinor, Boon, Elles, Pals, Steven, Sancho, Elena, Jonkeer, Suzanne, Malats, Nuria, Gregorieff, Alexander, Born, Maaike van de
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Development and progression, Colorectal cancer, Gene mutations, Gene mutation, Tumor suppressor genes, Tumour suppressor genes

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Identification of stem cells in small intestine and colon by marker gene Lgr5

Article Abstract:

The lineage-tracing experiments performed in adult mice by using inducible Cre knock-in allele and the Rosa26-lacZ reporter strain are reported. Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5), a marker gene identified stem cells expressed in the small intestine and colon cancer.

Author: Clevers, Hans, Begthel, Harry, Korving, Jeroen, Peters, Peter J., Barker, Nick, van Es, Johan H., Kuipers, Jeroen, Kujala, Pekka, van den Born, Maaike, Cozijnsen, Miranda, Haegebarth, Andrea
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Health aspects, Stem cells, Epithelium, Colon cancer, Small intestine cancer

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The Wntlbeta-catenin pathway regulates cardiac valve formation

Article Abstract:

Adenomatous polyposis coli (Apc) constitutively activates the Wnt/beta-catenin. Examples of embryos of mice with truncated Apc, do not complete gastrulation. The effect of truncated Apc, on zebrafish development is discussed.

Author: Begthel, Harry, Huristone, Adam F.L., Haramis, Anna-Pavlina G., Wlenholds, Erno, Korving, Jeroen
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Influence, Polyposis, Familial, Familial polyposis, Zebra fish, Zebra fishes

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Subjects list: Research, United States, Genetic aspects
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