Epigenetic silencers and notch collaborate to promote malignant tumors by Rb silencing

Article Abstract:

Tumorigenesis in the Drosophila eye is studied to identify two Polycomb group epigenetic silencers, pipsqueak (psq) and lola that participate in the inactivation of tumor-suppressor genes. The expression of the gene Retinoblastoma-family protein (Rbf) is downregulated in the malignant tumors and is associated with DNA hypermethylation and the results establish a mechanism that links the Notch-Delta pathway, epigenetic silencing pathways and cell-cycle control in the process of tumorigenesis.

Tumor suppressor genes, Retinoblastoma, Tumour suppressor genes

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

Article Abstract:

Signaling by Wnt receptor proteins (LRP5 and LRP6) has diverse roles in embryos and in adults and is implicated in human diseases and the coupling of these receptors with cytoplasmic signaling apparatus is not clear. Using a protein modification screen for regulators of LRP6 identification of Casein kinase 1 gamma is described.

Dry, Condensed, and Evaporated Dairy Product Manufacturing, Dry, condensed, evaporated products, Casein, Analysis, Physiological aspects, Cytogenetics, Structure, Transduction, Transduction (Genetics)

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