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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

Article Abstract:

The importance of the mitochondrial apoptosis-inducing factor in programmed cell death is researched.

Author: Kong, Young-Yun, Wakeham, Andrew, Elia, Andrew J., Mak, Tak W., Kroemer, Guido, Sasaki, Takehiko, Penninger, Josef M., Joza, Nicholas, Susin, Santos A., Daugas, Eric, Stanford, William L., Cho, Sarah K., Li, Carol Y.J., Mary Cheng, H.Y., Ravagnan, Luigi, Ferri, Karine, F., Zamzami, Naoufal, Hakem, Razqallah, Yoshida, Hiroki, Zuniga-Pflucker, Juan Carlos
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001

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ICOS is essential for effective T-helper-cell responses

Article Abstract:

A new study seeks to determine the physiological function of inducible co-stimulatory molecule (ICOS) in mice.

Author: Itie, Annick, Ohashi, Pamela S., Pawson, Tony, Wakeham, Andrew, Mak, Tak W., Ho, Alexandra, Penninger, Josef M., Tafuri, Anna, Shahinian, Arda, Bladt, Friedhelm, Yoshinaga, Steve K., Jordana, Manel, Boucher, louis-Martin, Bouchard, Denis, Chan, Vera S.F., Duncan, Gordon, Odermatt, Bernhard, Horan, Tom, Whoriskey, John S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Immunity, Immunity (Physiology), T cells

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Molecular characterization of mitochondrial apoptosis-inducing factor

Article Abstract:

Mitochondria are important in the control of cell death, or apoptosis.An apoptosis-inducing factor (AIF), able to induce apoptosis of isolated nuclei, has been identified and cloned. The AIF flavoprotein can translocated to the nucleus when apoptosis is induced. Recombinant AIF leads to chromatin condensation and large scale DNA fragmentation. Purified mitochondria are induced to release cytochrome c and caspase-9. The wide-ranging caspase inhibitor Z-VAD.fmk. does not prevent any of those effects.

Author: Penninger, Josef, Aebersold, Ruedi, Kroemer, Guido, Siderovski, David P., Susin, Santos A., Zamzami, Naoufal, Goodlett, David R., Brothers, Greg M., Lorenzo, Hans K., Marzo, Isabel, Snow, Bryan E., Mangion, Joan, Jacotot, Eitenne, Costantini, Paola, Loefller, Markus, Larochette, Nathanael
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
Mitochondria

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Subjects list: Research, Cell death
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