Expression of recombinant dystrophin and its localization to the cell membrane

Article Abstract:

Duchenne's muscular dystrophy (DMD) is an inherited disease, primarily affecting males, that causes muscle atrophy. The gene that is defective in DMD and another type of muscular dystrophy, Becker's muscular dystrophy, has been isolated and characterized. The gene encodes a protein found in muscles, known as dystrophin. The function of dystrophin is not known, but the location of dystrophin is known to be on the inside of the cell membrane. Dystrophin interacts with other proteins of the cell membrane. The gene encoding the entire dystrophin molecule, which is a large molecule, has been synthesized and expressed in cells grown in tissue culture. This synthesized molecule appears to be identical to the original dystrophin molecule. Further studies of the structure and function of dystrophin can be conducted with this molecule. The gene that encodes the entire dystrophin molecule may possibly be used for gene therapy, where it would be given to patients with DMD and Becker's muscular dystrophy to correct the deficiency due to the defective gene. (Consumer Summary produced by Reliance Medical Information, Inc.)

Genetic aspects, Identification and classification, Cell membranes, Duchenne muscular dystrophy, Muscular dystrophy, Dystrophin, Becker muscular dystrophy

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Erythropoietin abuse in athletes

Article Abstract:

The illicit use of erythropoietin among athletes has become prevalent. Recombinant human erythropoietin is preferred by athletes for its ability to artificially enhance performance. Results of a new study on the soluble transferrin receptor, which reveal that erythropoietin yields remarkable changes in the serum soluble transferrin receptor content, are seen to be useful in designing a probe to detect misuse of erythropoietin.

Dosage and administration, Erythropoietin, Drugs and athletes

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Recombinant erythropoietin in urine

Article Abstract:

A new technique for detecting recombinant human erythropoietin (EPO) in urine following its recent administration is presented. A new immunoblotting procedure makes it possible to obtain a reliable image of EPO patterns in urine.

Athletes, Drug testing, Erythropoietin, Recombinant, Recombinant erythropoietin

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