Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1

Article Abstract:

Transgenic mice selectively overexpressing in skeletal muscle the 4q35 genes FRG1, FRG2 or ANT1 are generated to identify the gene responsible for facioscapulohumeral muscular dystrophy (FSHD) pathogenesis. It is found that FRG1 transgenic mice develop a muscular dystrophy while FRG2 and ANT1 mice seem normal, suggesting that FSHD results from inappropriate overexpression of FRG1 in skeletal muscle, leading to abnormal alternative splicing of specific pre-mRNAs.

Massachusetts, Psychological aspects, Genetically modified mice, Cell culture, Muscular dystrophy

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An elaborate pathway required for Ras-mediated epigenetic silencing

Article Abstract:

Studies are conducted to identify the genes required for Ras-mediated epigenetic silencing of the pro-apoptotic Fas gene. The findings reveal that nine Ras epigenetic silencing effectors are required for anchorage-independent growth and tumorigenicity of K-ras-transformed NIH 3T3 cells.

Analysis, Polymerase chain reaction, Ras genes, Epigenetic inheritance

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Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3

Article Abstract:

The ability of the TATA-box binding protein (TBP)-related factor 3, Trf3 to initiate the zebrafish haematopoiesis is discussed.

Protein binding, Animal embryology, Hematopoiesis, Zebra fish, Zebra fishes

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