Failure of a single-headed kinesin to track parallel to microtubule protofilaments

Article Abstract:

Experimental studies using truncated kinesin derivatives containing either two mechanochemical head domains or only a single head reveal that one-headed enzyme often fails to track microtubule protofilaments, indicating its detachment from microtubules during movement. A 'hand-over-hand' mechanism accounts for the efficiency of single two-headed kinesin molecules to induce continuous movement. In two-headed kinesin molecules, one head detaches from the microtubule and moves forward, while the other is attached to the microtubule.

Enzymes, Kinesin, Enzyme structure-activity relationships

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x-sequence recognition and DNA translocation by single RecBCD helicase/nuclease molecules

Article Abstract:

X-sequence recognition and DNA translocation by single RecBCD helicase molecules is reported.

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Processive translocation and DNA unwinding by individual RecBCD enzyme molecules

Article Abstract:

Individual RecBCD enzyme molecules exhibit processive translocation and DNA unwinding.

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