Fbxw71Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Article Abstract:

The study identifies the mouse Fbxw7 gene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Further, it proposes that p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers.

Tumor suppressor genes, Tumour suppressor genes

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Surveillance team against cancer

Article Abstract:

Researches show that the impairment of normal parental imprinting might interfere with cellular differentiation and thereby increase the probability of cancerous development. The findings also reveal that mutation of a 'cancer gene' adenomatous polyposis coli (APC) and an epigenetically imposed delay in cell differentiation might drive tumor development synergistically.

Causes of, Development and progression, Carcinogenesis, Oncogenes

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Profile of a tumour

Article Abstract:

The investigation of the role of human genes in cancer has become possible, due to the increasing number of cancer research projects undertaken. Also a research on the proteomic profiling of blood serum is conducted.

Genetic research

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