G-protein-coupled receptor heterodimerization modulates receptor function

Article Abstract:

Western blotting has been used to analyze lysates from cells expressing kappa-receptors tagged with a Flag to establish whether kappa-receptors exist as dimers. It was established that most kappa-receptors exist as dimers of relative molecular mass 130,000, irrespective of the presence or absence of a crosslinker. Research based on this finding provides biochemical and functional evidence for opioid-receptor heterodimerization. The heterodimers show greatly reduced affinities for their selective ligands.

Opioids, Opioid receptors

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Insulin action impaired by deficiency of the G-protein subunit Gialpha2

Article Abstract:

A study was conduced on the metabolic effects of protein subunit Gialpha deficiency on transgenic mice. Gialpha2 deficiency in adipose tissue and liver was found to induce hyperinsulinaemia, in vivo insulin resistance and glucose tolerance impairment. Results also indicated a relationship between the G-protein and tyrosine kinase signalling cascades. An antisense RNA expression system for investigating G protein functions in insulin-sensitive tissues was developed.

Physiological aspects, Insulin

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