Genetic enhancement of learning and memory in mice

Article Abstract:

The N-methyl-D-aspartate (NMDA) receptor acts as a graded molecular switch for gating the age-dependent threshold for synaptic plasticity and memory function in mice. This finding provides strong confirmation for Hebb's learning rule. It was established that overexpression of NMDA receptor 2B in the forebrains of transgenic mice induces enhanced activation of NMDA receptors. This allows synaptic potentiation in response to stimulation at 10 Hz to 100 Hz. Neural activities at this range in the forebrain could be essential for coding and storing learned information.

Neuroplasticity, Methyl aspartate, N-methyl-D-aspartate

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Targets of the cyclin-dependent kinase Cdk1

Article Abstract:

Cyclin-dependent kinases (Cdks) control the cell cycle by catalyzing the transfer of phosphate from ATP to specific protein substrates. Detailed analysis of the Cdk1 substrates are provided which are likely to yield important insights into cell-cycle regulation.

Analysis, Cellular control mechanisms, Cell regulation, Ring formation (Chemistry), Cyclization (Chemistry)

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

Article Abstract:

Research is presented concerning the difficulties of developing a technique for the inhibition of protein kinases through specific inhibitors. A chemical genetic strategy to overcome this difficulty is discussed.

Physiological aspects, Biochemical genetics, Protein kinases, Letter to the Editor, Enzyme inhibitors

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