Glycosylation with a twist

Article Abstract:

The chemical reaction of sugars linked together resulting in glycoside molecules are formidable and a set of more strong chemical reactions that can generate the full complement of glycosidic linkages are yet to be found out by synthetic chemists. A different method by Boons and colleagues, which could fill a major gap in the chemical tool kit required for efficient synthesis of many glycosides that occur in nature, is described in their Journal of American Chemical Society.

Glycosylation, Glycosides

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Exploring life's sweet spot

Article Abstract:

The three main classes of repeating biopolymers are nucleic acids, proteins and carbohydrates. Speedy access to sufficient quantities of defined carbohydrates allows the creation of tools that are commonplace in genomics and proteomics and carbohydrate arrays that present synthetic content for high-through-put screening are used to analyze interactions between carbohydrates and proteins and the sugar chips have yielded, as fingerprints of carbohydrate-binding proteins.

Biopolymers, Glucose, Structure, Binding proteins, Glucose synthesis

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Synthesis and medical applications of oligosaccharides

Article Abstract:

The report about the carbohydrate sequencing and the synthesis of defined oligosaccharides, which are the two key technologies contributing to progress in glycomics research is reviewed. The observations suggest that these techniques could be applied to the development of carbohydrate-based diagnostics, vaccines and therapeutics.

Analysis, Oligosaccharides, Glycolysis

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