Gout-associated uric acid crystals activate the NALP3 inflammasome

Article Abstract:

Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) engage the caspase-1-activating NALP3 inflammasome, resulting in the production of active interleukin (IL)-1beta and IL-18. Studies provide insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, and further support a pivotal role of the inflammasome in several auto-inflammatory diseases.

Inflammatory bowel diseases, Uric acid, Pyrophosphates, Chemical properties

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Interference with Al-2-mediated bacterial cell-cell communication

Article Abstract:

Study is conducted to show that some species of bacteria can manipulate autoinducer-2 (Al-2) signaling and interfere with other species' ability to assess and respond correctly to changes in cell population density. Al-2 signaling, and the interference with it, could have important ramifications for eukaryotes in the maintenance of normal microflora and in protections from pathogenic bacteria.

Analysis, Host-bacteria relationships, Quorum sensing

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Glycan-based interaction involving vertebrate sialic-acid-recognizing proteins

Article Abstract:

Studies to understand and classify the cellular interactions that are mediated by glycans and proteins that improve the understanding of normal physiology, disease and human evolution were conducted. Proteins that bind sialic acid are involved in a broad range of biological processes including intercellular adhesion, signalling and microbial attachment.

Cell interaction, Cell interactions, Sialic acids, Protein-protein interactions

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