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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Article Abstract:

It is reported that the sonic hedgehog, a secreted hedgehog ligand, is abnormally expressed in pancreatic adenocarcinoma and its precursor lesions: pancreatic intraepithelial neoplasia. The maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis.

Author: Roberts, Drucilla J., Lauwers, Gregory Y., Thayer, Sarah P., Heiser, Patrick W., Nielsen, Corinne M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Ligands (Biochemistry), Hedgehogs

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Detection of preinvasive cancer cells

Article Abstract:

Issues are presented concerning the detection of preinvasive cancer cells through the use of light-scattering spectroscopy. The optical-probe technique's ability to detect early cancerous changes in epithelia is discussed.

Author: Backman, V., Wallace, M.B., Perelman, L.T., Arendt, J.T., Gurjar, R., Muller, M.G., Zhang, Q., Zonios, G., Kline, E., McGillican, T., Shapshay, S., Valdez, T., Badizadegan, K., Crawford, J.M., Fitzmaurice, M., Kabani, S., Levin, H.S., Seiler, M., Dasari, R.R., Itzkan, I., Van Dam, J., Feld, M.S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Spectrum analysis, Spectroscopy, Cancer diagnosis

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Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

Article Abstract:

Research is presented concerning the influence of genomic integrity and senescence of human mammary epithelial cells in preventing the development of malignant lesions. Growth after senescence is discussed.

Author: Romanov, Serguei R., Kozakiewicz, B. Krystyna, Holst, Charles R., Stampfer, Martha R., Haupt, Larisa M., Tlsty, Thea D.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Research, Cells, Precancerous conditions, Letter to the Editor, Cell aging

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Subjects list: Diagnosis, Cancer, Abnormalities, Epithelial cells, Dyskeratosis congenita
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