High-fidelity transmission of sensory information by single cerebellar mossy fiber boutons

Article Abstract:

The analysis on the method to make direct patch-clamp recordings in vivo from cerebellar mossy fiber boutons, that results in bursts of spikes in single boutons at very high instantaneous firing frequencies, is described. It is concluded that the relay from the mossy fiber to granule cell can act in a 'detonator' manner in which a single presynaptic afferent is enough to send the sensory message, giving the cerebellar mossy fiber system with remarkable sensitivity and high fidelity in the transmission of sensory information.

Usage, Synapses, Sensory stimulation, Patch clamp techniques

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Controlling neural circuits with light

Article Abstract:

Two light-sensitive proteins from unicellular organisms were harnessed to rapidly activate or silence neurons and show that optical remote control allows precise, millisecond control of neural circuits. The results showed that it is possible to rapidly and reversibly silence or activate a particular neuronal subtype with light and simultaneously observe the effect on behavior.

United States, Neural circuitry, Unicellular organisms

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