Homing in on the homeobox
Article Abstract:
Exactly how the homeobox DNA sequence brings about the formation of various animal phyla's body plans was the subject of a recent gathering of biologists. The meeting, called the 'EMBO Workshop: The Homeobox and the Genetic Control of Development,' was held in Ascona, Switzerland on May 24-30, 1992. Participants discussed how the homeodomain folds into three alpha-helices, with the second two having a helix-turn-helix conformation typical of most DNA-binding proteins. In addition, new research suggested how the homeodomain proteins affect the patterning of tissues in diverse organisms.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene
Article Abstract:
The disruption of the Hox gene in mice causes the occipital bones of the skull to develop abnormally but only in regions anterior to the gene's usual area of expression. The ectopic expression of Hox 4.2 induces a homeotic alteration of the occipital bones into a posterior phenotype similar in shape to the cervical vertebrae. However, no such change affects structures ordinarily controlled by Hox 4.2. Thus, it is manifest that posterior Hox genes can reconfigure anterior skeletal arrangements.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Nested expression domains of four homeobox genes in developing rostral brain
Article Abstract:
Two homeobox genes, Otx1 and Otx2, act with two other previously identified homeobox genes, Emx1 and Emx2, to control development of the rostral brain in mice and are homologous with orthodenticle and empty spiracle genes in Drosophila. Thus some vertebrate and invertebrate homeobox genes are now known to be homologues. The four genes govern expression of several regions of the brain including the telencephalon. The genes' expression domains progress in the sequence Emx1, Emx2, Otx1 and Otx2.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Assessing the redundancy of MADS-box genes during carpel and ovule development. SHATTERPROOFMADS-box genes control seed dispersal in Arabidopsis
- Abstracts: Molecular cloning and expression of the gene for a human D1 dopamine receptor. Cloning and expression of human and rat D1 dopamine receptors
- Abstracts: Doubling the critical temperature of La1.9Sr0.1CuO4 using epitaxial strain. Direct observation of the alignment of ferromagnetic spins by antiferromagnetic spins
- Abstracts: Embalming was used in Old Kingdom. Analysis of a pharaonic embalming tar. Organic chemistry of embalming agents in Pharaonic and Graeco-Roman mummies
- Abstracts: Not only gone with the wind. Feeding patterns on forest floors. How to get carried away