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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

Article Abstract:

A novel class of methylated H3K4 effector domains, the PHD domains of the ING (for inhibitor of growth) family of tumor suppressor proteins, are identified, wherein the ING PHD domains are specific and highly robust binding molecules for trimethylated lysine 4 of histone H3 (H3K4me3). ING2 modulates cellular responses to genotoxic insults and DNA damage through functions critically dependent on ING2 interaction with H3K4me3, establishing that trimethylation of H3K4 is pivotal in gene repression.

Author: Ayer, Donald E., Fei Lan, Lacoste, Nicolas, Cote, Jacques, Gozani, Or, Chua, Katrin F., Cairns, Bradley R., Yang Shi, Tao Hong, Xiaobing Shi, Walter, Kay L., Ewalt, Mark, Michishita, Eriko, Hung, Tiffany, Carney, Dylan, Pena, Pedro, Kaadige, Mohan R., Cayrou, Christelle, Davrazou, Foteini, Saha, Anjanabha, Kutateladze, Tatiana G.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
California, Health aspects, Analysis, Gene expression, Tumor suppressor genes, Tumour suppressor genes

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Coordinated histone modifications mediated by a CtBP co-repressor complex

Article Abstract:

Study of the mechanics of oncogenic transformation reveals that transcriptional co-repressor CtBP is targeted by the adenovirus during tumorigenesis. The article provides supporting illustrations of the process, as well as details of the experimental methods used.

Author: Shi, Yang, Nakatani, Yoshihiro, Yujiang, Shi, Sawada, Jun-ichi, Sui, Guangchao, Affar, El Bachir, Whetstine, Johnathan R., Fei Lan, Ogawa, Hidesato, Luke, Margaret Po-Shan
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Cancer, Cancer genetics, Carcinogenesis, Pathology

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A histone H3 lysine 27 demethylase regulates animal posterior development

Article Abstract:

The regulation of animal anterior-posterior development by the histone H3 lysine 27 demethylases is discussed. These enzymes are found to be very beneficial for the regulation of histone methylation dynamics as well.

Author: Chang, Howard Y., Roberts, Thomas M., Whetstine, Johnathan R., Fei Lan, Rinn, John L., Canaani, Eli, Wang, Jordon K., Yang Shi, Alpatov, Roman, Bayliss, Peter E., Shuzhen Chen, Iwase, Shigeki, Issaeva, Irina
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Fibroblasts, Embryology, Human, Human embryology

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Subjects list: Research, Genetic aspects, Histones, Methylation
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