Abstracts - faqs.org

Abstracts

Zoology and wildlife conservation

Search abstracts:
Abstracts » Zoology and wildlife conservation

Identification of the breast cancer susceptibility gene BRCA2

Article Abstract:

The breast cancer susceptibility gene BRCA2 is present on the 13q12-q13 chromosome. Six different mutations detected in the breast-cancer families are due to the BRCA2 gene. Northern analysis indicates that BRCA2 is encoded by a transcript of 10-12 kb, present in the normal breast epithelial cells, breast cancer cell line MCF7, and the placenta. The sequence of 2329 amino acid encoded by the BRCA2 gene is different from the normal DNA sequences. The mapping of BRCA2 is described.

Author: Narod, Steven, Smith, Amanda, Ashworth, Alan, Wooster, Richard, Peto, Julian, Bishop, D. Timothy, Ponder, Bruce A.J., Bentley, David R., Lenoir, Gilbert, Gregory, Simon, Eeles, Rosalind, Patel, Sandeep, Stratton, Michael R., Futreal, P. Andrew, Mangion, Jonathan, Lancaster, Jonathan, Easton, Douglas F., Bignell, Graham, Lynch, Henry, Swift, Sally, Seal, Sheila, Collins, Nadine, Gumbs, Curtis, Micklem, Gos, Barfoot, Rita, Hamoudi, Rifat, Rice, Catherine, Biggs, Patrick, Hashim, Yasmin, Connor, Frances, Arason, Adalgeir, Gudmundsson, Julius, Ficenec, David, Kelsell, David, Ford, Deborah, Tonin, Patricia, Spurr, Nigel K., Devilee, Peter, Cornelisse, Cees, Egilsson, Valdgardur, Barkadottir, Rosa Bjork
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
Breast cancer, Mutation (Biology), Mutation

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Understanding the target

Article Abstract:

Mutations in the epidermal growth factor receptor gene (EGFR) in a subset of lung cancers make the disease more responsive to treatment. New studies provide evidence that most lung cancers that respond to gefitinib, have an activating EGFR mutation and the responses to gefitinib in clinical trials were not flukes.

Author: Stratton, Michael R., Futreal, P. Andrew
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Care and treatment, Lung cancer, Epidermal growth factor receptors

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Chromosomally unstable mouse tumors have genomic alterations similar to diverse cancers

Article Abstract:

The article explains how mouse models and human cancers were compared to study the alterations connected to cancer by using multiple genome analysis technologies.

Author: Maser, Richard S., Chin, Lynda, Stevens, Claire, Brennan, Cameron, Stratton, Michael R., Futreal, P. Andrew, Campbell, Peter J., Martin, Eric S., Look, Thomas A., Nogueira, Cristina, Edkins, Sarah, Choudhury, Bhudipa, Duke, Veronique, Mansour, Marc, Ivanova, Elena, Wang, Yaoqi A., Rowe, Jacob M., Histen, Gavin, Jiang, Shan, Mani, Vidya, Lin, Eric, Perna, Ilana, McNamara, Kate, Zaghlul, Sara, Depinho, Ronald A., Wiedemeyer, Ruprecht, Kabbarah, Omar
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Health aspects, Mice, Tumors, House mouse, Genetic research, Tumours, Mouse leukemia complex

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Genetic aspects, Research, United States
Similar abstracts:
  • Abstracts: X-activation profile reveals extensive variability in X-linked gene expression in females
  • Abstracts: Identification of a tumour suppressor network opposing nuclear Akt function. Taking apart a cancer protein
  • Abstracts: Opening the gap. Quantum criticality. Turn up the temperature
  • Abstracts: Conflicts at the NIH (cont.). Academic diversity. Painful transition at the NIH
  • Abstracts: Radiation nation. Nature's guide for mentors. From rags to research
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2025 Advameg, Inc.