IgD can largely substitute for loss of IgM function in B cells

Article Abstract:

IgD is largely capable of substituting for the functions of IgM, the other first antibody isotype expressed during bone-marrow B-cell development, in relation to B-cell development, maturation and function. It therefore appears that there is redundancy between these isotypes. IgM-/- mice show no changes in morphology or cell numbers in lymphatic organs compared with wild-type controls. Fluorescence-activated cell sorting analysis of bone-marrow cells from IgM-/- mice showed a normal number and distribution of B-cell receptor-negative pro-B and pre-B cells.

Research, B cells

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Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

Article Abstract:

A study of how certain non- or poorly cytopathic viruses can persist in their hosts is reported. The study protocol involved observing the cytotoxic T lymphocyte responses of adult mice to acute infection with the noncytopathic lymphocytic choriomeningitis virus (LCMV). The results showed that some strains of LCMV persist in the host after acute infection without causing lethal immunopathological disease. It seems that the virus induces most of the specific antiviral cytotoxic T lymphocytes, thus causing complete exhaustion of T-cll immunity.

Viruses

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

Article Abstract:

Results show that apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G) expressed in human T lymphocytes participates in HIV inhibition by exerting antiviral effect during reverse transcription triggering guanine to adenine hypermutation in the newly synthesized retroviral DNA.

Switzerland, Prevention, Genetic aspects, Mutation (Biology), Mutation, Virus replication, Defense reaction (Physiology), Retrovirus infections, Defence reaction (Physiology)

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