Imaging of radiocarbon-labelled tracer molecules in neural tissue using accelerator mass spectrometry

Article Abstract:

The imaging of C14-labeled tracers in sections of biological tissue involves the bombarding of the tissue by a gallium ion beam. Accelerator mass spectrometry detects 14C ions in the sputtered constituent atoms, molecules and secondary ions of the beam. The technique may be considered as a specialized form of scanning secondary ion mass spectrometry. A scan takes 10-20 minutes and reveals individual axons, glial cells and neurons at high sensitivity. The method can be combined with methods such as immunocytochemistry for multiple labeling.

Usage, Imaging systems, Nerve tissue, Radioactive tracers, Secondary ion mass spectrometry

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Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons

Article Abstract:

GABAergic interneurons can suitably synchronize hippocampal pyramidal cell activities at theta frequencies. The process of synchronization involves the interaction of intrinsic oscillatory mechanisms with GABA(sub A)-receptor-regulated hyperpolarizing synaptic events. Multiple aggregates of action potentials after single i.p.s.p. reveal that hyperpolarization restarts an intrinsic rhythmic response instead of slowing the onset of action-potential production.

Physiological aspects, Hippocampus (Brain), GABA, GABA receptors

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Preferential representation of the fovea in the primary visual cortex

Article Abstract:

The retinal fovea in mammals represents 0.01% of the retinal area but is represented by 8% of the striate cortex. Using a retrograde transneuronal tracer, ganglion cells near the fovea were found to be linked to 3.3 to 5.9 times more cortical tissue than peripheral ganglion cells. Though the ganglion cells of the fovea receive preferential cortical representation, the fovea is represented much more than suggested by ganglion cell treatment.

Brain, Visual cortex, Localization (Brain function), Brain mapping

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