Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

Article Abstract:

Natural killer (NK) cells express immunoglobulin and C-type lectin cell surface receptors, recognizing major histocompatibilty complex (MHC) class I peptides, inhibiting NK-cell-mediated cytotoxicity. It is shown that the disulphide-bonded homodimer DAP12, containing an immunoreceptor tyrosine-based activation motif (ITAM) within its cytoplasmic domain, links non-covalently with membrane glycoproteins of the killer-cell inhibitory receptor family, without ITIM. Cellular activation results from the crosslinking of KIR-DAP12 complexes.

Observations, Killer cells, Tyrosine

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Convergent evolution of cytokines

Article Abstract:

Murine monoclonal antibodies were used to detect putative immunoreactive components in the coelomic fluid of Eisenia foetida, the earthworm, to test fo invertebrate molecules with lectin specificity similar to TNF-alpha. Both CCF-1 and TNF-alpha have opsonizing properties, binding beta-1,3 glucan via a lectin-like interaction. CCF-1 and TNF-alpha also share an N/N'-diacetylchitobiose lectin-like activity, but do not show genetic homology.

Research, Physiological aspects, Cytokines, Earthworms

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