Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins

Article Abstract:

Beta1-integrin cells were not found in blood and in haematopoietic organs such as spleen, thymus and bone marrow in chimaeric mice generated with beta1-integrin-deficient embryonic stem cells. Chimaeric embryos in the yolk sac and fetal blood have beta1-null haematopoietic cells, but not in fetal liver. These beta1(-/-) haematopoietic stem cells derived from yolk sac of chimaeric embryos generate erythroid and myeloid colonies. Beta1(-/-) embryonic stem cells can also differentiate into mature B lymphocytes in vitro. These suggest that haematopoietic stem cells with no beta1 integrins do not affect blood cell differentiation. However, colonization of fetal liver cannot be achieved since beta1 integrins are vital in this process.

Blood cells

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Article Abstract:

A demonstration that activation of phosphatase and tensin homologue (PTEN) in bone marrow Haematopoietic stem cells (HSCs) causes their short-term expansion, but long-term decline, primarily owing to an enhanced level of HSC activation is presented. HSC must achieve a balance between quiescence and activation that fulfils immediate demands for haematopoiesis without compromising long-term stem cell maintenance.

Science & research, Care and treatment, Prevention, Leukemia, Hematopoietic stem cell transplantation

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