Imprinting in leukaemia

Article Abstract:

Chronic myeloid leukemia, a form of hematological malignancy, is the genetic result of genomic imprinting or the parent-specific expression or repression of genes or chromosomes in progeny. Oskar A. Haas and colleagues found that this form of leukemia features a reciprocal chromosome translocation. This translocation produces the Philadelphia chromosome that is characteristic of chronic myeloid leukemia. Furthermore, a translocated chromosome 9 will derive from the father's family whereas a translocated chromosome 22 will usually derive from the mother's family.

Genetic aspects, Translocation (Genetics), Myeloid leukemia, Philadelphia-positive, Philadelphia-positive myeloid leukemia

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Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome

Article Abstract:

The IGF2 gene, encoding a fetal insulin-like growth factor has been implicated in Beckwith-Wiedemann syndrome, a human fetal overgrowth syndrome. Igf2 transgenes were introduced into the mouse genome, using embryonic stem cells. The overexpression of Igf2 led to most of the symptoms of Beckwith-Weidemann syndrome, establishing Igf2 overexpression as a key factor of Beckwith-Weidemann syndrome.

Genetically modified mice, Beckwith-Wiedemann syndrome

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Silence across the border

Article Abstract:

Research into the role of chromatin boundaries in genomic imprinting is presented. It is now known that the imprinting arsenal includes enhancers, promoters, silencers, antisense RNA transcripts and chromatin boundaries.

Chromatin, Genetic markers

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