Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Article Abstract:

Huntington's disease (HD), a neurodegenerative disorder caused by an abnormal polyglutamine (polyQ) expansion within the protein huntingtin (Htt), is characterized by the aggregation of Htt into microscopic intracellular deposits called inclusion bodies (IBs) and by the death of striatal and cortical neurons. When multiple effectors mediate pathogenesis, survival analysis provides a way to quantify the contribution of each factor, potentially helping to assess its individual pathogenic significance.

Causes of, Pathogenic microorganisms

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Coevolution with viruses drives the evolution of bacterial mutation rates

Article Abstract:

The article explains that the coevolution with viruses drives the evolution of bacterial mutation rates in the bacterium, Pseudomonas fluorescens. The results prove that the bacteriophages play a very important role in the evolution of bacterial mutation rates.

Analysis, Natural history, Bacteria, Viruses, Natural selection

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Toxic alert

Article Abstract:

Researchers are worried about the potential toxicity of the recombinase 'Cre' expression to cells. The Cre enzyme is a good technique that allows the introduction of mutations and gene deletions in a tissue or cell type at any stage.

Physiological aspects, Toxicity, Recombinases

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