Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia

Article Abstract:

Research with mice has shown that a certain mutant gene called Tabby (Ta) causes a syndrome which includes anhidrosis, an absence of sweat glands. Study of the human syndrome called hypohidrotic ectodermal dysplasia (HED) has related abnormal skin ridges to the absence of sweat glands. A lack of skin ridges was also noted in the Ta mutant mice. It has been found that a substance called epidermal (skin) growth factor (EGF) can induce the growth of skin ridges and sweat glands in a related strain of research mice. The Ta mutation and the HED mutation genes seem to be closely related. Disruption of the normal EGF production and function is the proposed hypothesis for the Ta mutation, and possibly the HED mutation. The reversal of this syndrome in research mice has important implications for the treatment of infants born with HED, which is life-threatening when extreme fever results. It is suggested that other treatment regimens, such as a combination of EGF with retinoic acid, may achieve even better results. (Consumer Summary produced by Reliance Medical Information, Inc.)

Care and treatment, Causes of, Skin diseases, Anhidrosis

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Cell-free activation of a DNA-binding protein by epidermal growth factor

Article Abstract:

Epidermal growth factor (EGF), which stimulates cell-surface receptors with intrinsic tyrosine kinase, also activates DNA-binding protein in a system without cells. Moreover, EGF activation occurs under conditions that demand ligand, receptor, adenosine triphosphate and phosphotyrosine-src-homology-2 interactions as prerequisites for DNA binding. The cause of this activation has not been detected.

DNA binding proteins

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Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons

Article Abstract:

A male-specific 7-kDa peptide secreted from the extraorbital lacrimal gland is identified. The peptide, which is named exocrine gland-secreting peptide 1 (ESP1), is encoded by a gene from a large family clustered in proximity to the class I major histocompatibility complex (MHC) region.

United States, Genetic aspects, Sensory receptors, Exocrine glands, Lacrimal apparatus

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