Inositol trisphosphate and calcium signalling

Article Abstract:

Cellular calcium signalling is regulated in large part by the second messenger inositol trisphosphate (InsP3). Knowledge of InsP3's functions has grown significantly since its role in cellular usage of calcium was first demonstrated in 1983. Cells generate InsP3 through one of two pathways: the G protein-associated receptors and the tyrosine kinase-associated receptors. Moreover, InsP3-calcium signalling may affect a variety of cellular processes including fertilization and growth.

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Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca2+ release

Article Abstract:

Calcium 2+ ions (Ca2+) are released to help trigger cellular signal transduction through a feedback mechanism in which inositol 1,4,5-trisphosphate (InsP3) plays the crucial part. Fluorometry of fluo-3 analysed the production of Ca2+ from permeabilized smooth muscle and found that InsP3 regulates and reinforces the process. The feedback limitations allow InsP3-induced Ca2+ production to intensify the cellular signal.

Calcium ions

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Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites

Article Abstract:

Research shows that calcium is released in postsynaptic cerebellar Purkinje neurons after synaptic inositol-1,4,5-trisphosphate (InP3) stimulation. InP3 appears to have a limited range, affecting local parallel fibre nerve synapses. InP3 may function in long-term depression within the nerve. Patch-clamp recording techniques were used on rat brain material.

Purkinje cells

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