Inside the gearbox of the dendritic cell

Article Abstract:

Dendritic cells could hold the key to the induction of T-cell responses. Cella at colleagues demonstrate how environmental factors can cause dendritic cells to redirect their antigen-processing properties, maximizing T-cell triggering capacity. New insights into the organization of class II major histocompatibility complex (MHC) maturation, expression and stability is also provided, using in vitro methods for generating immature dendritic cells. These new studies may be relevant to the use of dendritic cells in clinical immunotherapy.

Usage, Physiological aspects, Antigen presenting cells, Immunotherapy

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Engineering cyclophilin into a proline-specific endopeptidase

Article Abstract:

A new catalytic activity has been engineered into an Escherichia coli cyclophilin, through the mutation of three amino acids, forming a catalytic triad. The cyclophilin has proline-bearing peptides specificity, creating a unique endopeptidase, cypropoase 1. It cleaves peptides on the amino-side of proline residues and enhances the rate of reaction, depending on a deprotonated histidine.

Research, Observations, Enzymes, Cyclophilin

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