Insulin resistance and obesity
Article Abstract:
It has been established that people affected by the loss-of-function PPAR-gamma mutations have common elements of the 'insulin resistance syndrome.' However, a key feature of this syndrome that these people do not have is obesity. It thus appears that reduced PPAR-gamma signalling causes insulin resistance in the absence of obesity. There is a need for further information before it is possible to state that too much PPAR-gamma leads to obesity without the anticipated metabolic repercussions, while too little PPAR-gamma produces the metabolic consequences without obesity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Mechanisms linking obesity to insulin resistance and type 2 diabetes
Article Abstract:
The interactions between obesity, insulin resistance and [beta]-cell dysfunction that result in type 2 diabetes is explored in an attempt to lay a framework to consider approaches that might lessen the burden of these epidemics that threaten modern society. It is observed that genes responsible for obesity and insulin resistance interact with environmental factors like increased fat/caloric intake and decreased physical activity resulting in the development of obesity and insulin resistance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Mechanisms linking obesity with cardiovascular disease
Article Abstract:
The classical and less conventional risk factors within the scope of insulin resistance as a major contributing factor to the obesity-associated cardiovascular risk are discussed. It is seen that common pathways involved in the pathogenesis of obesity and cardiovascular disease include insulin resistance and low-grade inflammation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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